Climate change and its related mobility responses, both coined as one of the main public health crises of the 21st century, often have adverse, and sometimes beneficial, effects on health and health systems. Climate threats may also push those with the poorest health to places with fragmented access to health care, exacerbating their health needs. Health services often struggle to ensure adequate and equitable access to care for those affected, and to meet the changing needs of dynamic populations. A number of both indoor and outdoor worker populations may be particularly vulnerable to climate variations (emergency responders, health care workers, fire fighters, utility workers, farmers, manufacturing workers and transportation workers). Climate conditions can amplify existing health and safety issues and could lead to new unanticipated hazards including high temperatures, air pollution, extreme weather and natural disasters, and biological hazards. Work is central in people’s lives, integrally intertwined as it positively impacts the physical, mental, financial, and social health and well-being of individuals. The extent of the impact of climate change (e.g., climate-sensitive hazards) on human health is poor understood and there is little evidence examining it in the occupational health context. To address these challenges warrants an extensive, transdisciplinary approach including health, industry and government partners.